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Search Results for " troponin i "

4

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T24901	Troponin I (104-115) Ac-Gly-lys-phe-lys-arg-pro-pro-leu-arg-arg-val-arg-NH2,Tni peptide (104-115)
	Troponin I is a cardiac and skeletal muscle protein useful in the laboratory diagnosis of a heart attack. Troponin I is a part of the troponin protein complex, where it binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place.
T24115	GSK854 GSK-854,GSK 854	Apoptosis	Apoptosis
	GSK854 是一种具有高选择性和有效性的肌钙蛋白 I 相互作用激酶 (TNNI3K) 抑制剂，抑制小鼠心肌梗死损伤细胞焦亡和细胞凋亡，可限制缺血性心脏的氧化应激、损伤和不良重塑。
T71223	SR-33805
	SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. D...
T83043	Anti-MI/R injury agent 1
	Anti-MI/R injury agent 1 (compound 18) 是一种口服有效的人参三醇衍生物，专用于抗心肌缺血/再灌注 (MI/R) 损伤。该化合物能增强经氧-葡萄糖剥夺和再灌注 (OGD/R) 诱导心肌细胞损伤模型中的细胞活力，显着缩小大鼠心肌梗死面积，减少循环心肌肌钙蛋白 I (cTnI) 的释放，并减轻心脏组织损害。

化合物

Troponin I (104-115)

Cat.No: T24901

Synonym: Ac-Gly-lys-phe-lys-arg-pro-pro-leu-arg-arg-val-arg-NH2,Tni peptide (104-115)

Cat.No: T24115

Synonym: GSK-854,GSK 854

Target: Apoptosis

Cat.No: T71223

Anti-MI/R injury agent 1

Cat.No: T83043

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00044	TNNC1 Protein, Human, Recombinant (His) TNNC1,Troponin I,CMH7,TNNI	Human	E. coli
	Troponin I, also known as TNI, is a 24 kDa component of a protein complex on striated muscle thin filaments.Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin I inhibits the calcium-dependent muscle contraction mediated by Troponins...
TMPY-03957	Troponin C Protein, Human, Recombinant TN-C,CMD1Z,TNNC,TNC,CMH13,troponin C type ...	Human	E. coli
	Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin interactions and thereby mediating striated muscle relaxation. It binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place. Because of it myosin cannot bind actin in relaxed muscle. When calcium binds to the Troponin C it causes conformational changes which...
TMPH-02954	TNNI3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 40.1 kDa and the accession number is P48787.
TMPH-02956	TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc)	Mouse	E. coli
	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc) is expressed in E. coli expression system with N-10xHis-Flag and C-Myc tag. The predicted molecular weight is 29.6 kDa and the accession number is Q9WUZ5.
TMPH-02955	TNNI2 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. TNNI2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.2 kDa and the accession number is P13412.
TMPH-03282	TRIM63 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate...
TMPH-02634	TRIM63 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate...
TMPH-01271	TRIM63 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate...

重组蛋白

TNNC1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00044

Species: Human

Expression System: E. coli

Troponin C Protein, Human, Recombinant

Cat.No: TMPY-03957

Species: Human

Expression System: E. coli

TNNI3 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02954

Species: Mouse

Expression System: E. coli

TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc)

Cat.No: TMPH-02956

Species: Mouse

Expression System: E. coli

TNNI2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02955

Species: Mouse

Expression System: E. coli

TRIM63 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03282

Species: Rat

Expression System: E. coli

TRIM63 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02634

Species: Mouse

Expression System: E. coli

TRIM63 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01271

Species: Human

Expression System: E. coli

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